Colchicine EP Impurity E

Name: Colchicine EP Impurity E
Brand: Vaqora Chemicals
SKU: VQ-022257

About Colchicine EP Impurity E

Listed under CAS 7336-33-6, Colchicine EP Impurity E is a pharmacopeial impurity of Colchicine available from Vaqora Chemicals. The compound has the formula C21H23NO6, corresponding to a molecular weight of 385.4 g/mol. Its systematic (IUPAC) name is N-[(7S)-3-hydroxy-1,2,10-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide. Alternative names: 3-Demethyl Colchicine and Colchicine - Impurity E.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

Pharmaceutical QC and development laboratories use this impurity standard of Colchicine to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Colchicine

View every impurity, metabolite and intermediate we list for Colchicine.

Colchicine impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Colchicine EP Impurity E
Catalogue No.	VQ-022257
CAS Number	7336-33-6
IUPAC name	N-[(7S)-3-hydroxy-1,2,10-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
Molecular formula	C₂₁H₂₃NO₆
Molecular weight	385.4 g/mol
Exact mass	385.1525
Grade	Reference Standard
HSN code	38229090
InChIKey	JRRUSQGIRBEMRN-HNNXBMFYSA-N
SMILES	CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)O
PubChem CID	299664

Physical properties
Physical form	Solid
LogP (XLogP3)	0.7
H-bond donors / acceptors	2 / 6
TPSA	94.1 Å²
Synonyms	3-Demethyl Colchicine, Colchicine - Impurity E, 3-Demethylcolchicine, 3-Desmethylcolchicine, O3-Demethylcolchicine, 3-O-Demethylcolchicine, (-)-3-demethylcolchicine, Colchicine, O(3)-demethyl-, Desmethylcolchicine, O3-Demethyl colchicine, Colchiciine, 3-desmethyl-, Colchicine, O(sup 3)-demethyl-

Safety & hazard information (GHS)

Corrosive

Toxic

Health hazard

Signal word: Danger

Hazard statements

H300Fatal if swallowed
H318Causes serious eye damage
H330Fatal if inhaled
H340May cause genetic defects

Precautionary statements: P203, P260, P264, P264 + P265, P270, P271, P280, P284, P301 + P316, P304 + P340, P305 + P354 + P338, P316, P317, P318, P320, P321, P330, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Colchicine EP Impurity E?

The CAS Registry Number of Colchicine EP Impurity E is 7336-33-6. It is also known as 3-Demethyl Colchicine, Colchicine - Impurity E, 3-Demethylcolchicine.

What is the molecular formula and molecular weight of Colchicine EP Impurity E?

Colchicine EP Impurity E has the molecular formula C21H23NO6 and a molecular weight of 385.4 g/mol. Its IUPAC name is N-[(7S)-3-hydroxy-1,2,10-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide.

What is Colchicine EP Impurity E used for?

Colchicine EP Impurity E is supplied as a characterised reference material related to Colchicine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Colchicine EP Impurity E can I order?

We supply Colchicine EP Impurity E in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Colchicine EP Impurity E?

Yes. Every lot of Colchicine EP Impurity E is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Colchicine EP Impurity E be shipped internationally?

Yes. Colchicine EP Impurity E is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.