Ponatinib

Name: Ponatinib
Brand: Vaqora Chemicals
SKU: VQ-027556

About Ponatinib

Ponatinib (CAS 943319-70-8) is a high-purity reference standard of Ponatinib offered by Vaqora Chemicals. Formula C29H27F3N6O, molecular weight 532.6 g/mol. Alternative names: Ponatinib (AP24534) and 0LI.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

Laboratories use this Ponatinib standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

We offer Ponatinib in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide. A Safety Data Sheet (SDS) and technical specifications are available on request.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Ponatinib

View every impurity, metabolite and intermediate we list for Ponatinib.

Ponatinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Ponatinib
Catalogue No.	VQ-027556
CAS Number	943319-70-8
IUPAC name	3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide
Molecular formula	C₂₉H₂₇F₃N₆O
Molecular weight	532.6 g/mol
Exact mass	532.2198
Grade	Reference Standard
HSN code	38229090
InChIKey	PHXJVRSECIGDHY-UHFFFAOYSA-N
SMILES	CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5
PubChem CID	24826799

Physical properties
Physical form	Solid
LogP (XLogP3)	4.1
H-bond donors / acceptors	1 / 8
TPSA	65.8 Å²
Synonyms	Ponatinib (AP24534), 0LI, AP24534,Ponatinib, AP24534 (Ponatinib), EX-A067

Safety & hazard information (GHS)

Toxic

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H311Toxic in contact with skin
H331Toxic if inhaled
H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements: P203, P260, P261, P262, P264, P270, P271, P280, P301 + P316, P302 + P352, P304 + P340, P316, P318, P319, P321, P330, P361 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Ponatinib?

The CAS Registry Number of Ponatinib is 943319-70-8. It is also known as Ponatinib (AP24534), 0LI, AP24534,Ponatinib.

What is the molecular formula and molecular weight of Ponatinib?

Ponatinib has the molecular formula C29H27F3N6O and a molecular weight of 532.6 g/mol. Its IUPAC name is 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide.

What is Ponatinib used for?

Ponatinib is supplied as a characterised reference material related to Ponatinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Ponatinib can I order?

We supply Ponatinib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Ponatinib?

Yes. Every lot of Ponatinib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Ponatinib be shipped internationally?

Yes. Ponatinib is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.