Ponatinib N-Desmethyl Analog

Name: Ponatinib N-Desmethyl Analog
Brand: Vaqora Chemicals
SKU: VQ-021311

About Ponatinib N-Desmethyl Analog

Ponatinib N-Desmethyl Analog (CAS 943319-87-7) is a metabolite or degradation product of Ponatinib offered by Vaqora Chemicals. The compound has the formula C28H25F3N6O, corresponding to a molecular weight of 518.5 g/mol. It is also known as N-Desmethyl ponatinib or Desmethyl Ponatinib.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Good laboratory practice and suitable PPE are recommended during handling.

Analytical teams use this compound to identify metabolites and degradants of Ponatinib, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Ponatinib N-Desmethyl Analog is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Ponatinib

View every impurity, metabolite and intermediate we list for Ponatinib.

Ponatinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Ponatinib N-Desmethyl Analog
Catalogue No.	VQ-021311
CAS Number	943319-87-7
IUPAC name	3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]benzamide
Molecular formula	C₂₈H₂₅F₃N₆O
Molecular weight	518.5 g/mol
Exact mass	518.2042
Grade	Reference Standard
HSN code	38229090
InChIKey	KWRBKHJXXYLTAA-UHFFFAOYSA-N
SMILES	CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCNCC3)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5
PubChem CID	24826880

Physical properties
Physical form	Solid
LogP (XLogP3)	3.6
H-bond donors / acceptors	2 / 8
TPSA	74.6 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Ponatinib N-Desmethyl Analog?

The CAS Registry Number of Ponatinib N-Desmethyl Analog is 943319-87-7. It is also known as N-Desmethyl ponatinib, Desmethyl Ponatinib, Ponatinib Active Metabolite AP24567(M42).

What is the molecular formula and molecular weight of Ponatinib N-Desmethyl Analog?

Ponatinib N-Desmethyl Analog has the molecular formula C28H25F3N6O and a molecular weight of 518.5 g/mol. Its IUPAC name is 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]benzamide.

What is Ponatinib N-Desmethyl Analog used for?

Ponatinib N-Desmethyl Analog is supplied as a characterised reference material related to Ponatinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Ponatinib N-Desmethyl Analog can I order?

We supply Ponatinib N-Desmethyl Analog in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Ponatinib N-Desmethyl Analog?

Yes. Every lot of Ponatinib N-Desmethyl Analog is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Ponatinib N-Desmethyl Analog be shipped internationally?

Yes. We export Ponatinib N-Desmethyl Analog worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.