Cabozantinib Carboxylic Acid

Name: Cabozantinib Carboxylic Acid
Brand: Vaqora Chemicals
SKU: VQ-013277

About Cabozantinib Carboxylic Acid

Vaqora Chemicals supplies Cabozantinib Carboxylic Acid, a process intermediate or related compound of Cabozantinib registered under CAS number 849217-77-2, specified at 94% purity. Its molecular formula is C22H20N2O6 and its molecular weight is 408.4 g/mol. The IUPAC name is 1-[[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]carbamoyl]cyclopropane-1-carboxylic acid. Common synonyms include Des-4-fluorophenyl cabozantinib and Cabozantinib Des-O-fluoroaniline.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Good laboratory practice and suitable PPE are recommended during handling.

It is a process intermediate or related compound in the synthesis of Cabozantinib, useful for route development, impurity fate-and-purge studies and analytical method development. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide. This item is currently in stock for prompt dispatch.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development

Industries

Related to Cabozantinib

View every impurity, metabolite and intermediate we list for Cabozantinib.

Cabozantinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Cabozantinib Carboxylic Acid
Catalogue No.	VQ-013277
CAS Number	849217-77-2
IUPAC name	1-[[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]carbamoyl]cyclopropane-1-carboxylic acid
Molecular formula	C₂₂H₂₀N₂O₆
Molecular weight	408.4 g/mol
Exact mass	408.1321
Grade	Reference Standard
Purity / assay	94%
HSN code	2933
InChIKey	HXGYPQKHBCZWKO-UHFFFAOYSA-N
SMILES	COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)O
PubChem CID	57810164

Physical properties
Physical form	Solid
LogP (XLogP3)	3.4
H-bond donors / acceptors	2 / 7
TPSA	107 Å²
Synonyms	Des-4-fluorophenyl cabozantinib, 1-[[[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]amino]carbonyl]cyclopropanecarboxylic acid, 1-((4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylic acid, 1-((4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropanecarboxylic Acid, Cabozantinib Des-O-fluoroaniline, Cabozantinib metabolite M7, EXEL-5366, 1-(((4-((6,7-Dimethoxy-4-quinolinyl)oxy)phenyl)amino)carbonyl)cyclopropanecarboxylic acid, 1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylcarbamoyl]-cyclopropanecarboxylic acid, 1-[[4-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl]carbamoyl]cyclopropanecarboxylic Acid, US10273211, Compound 7, 1-[4-(6,7-Dimethoxyquinolin-4-yloxy)-phenylcarbamoyl]-cyclopropanecarboxylic acid

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Cabozantinib Carboxylic Acid?

The CAS Registry Number of Cabozantinib Carboxylic Acid is 849217-77-2. It is also known as Des-4-fluorophenyl cabozantinib, 1-[[[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]amino]carbonyl]cyclopropanecarboxylic acid, 1-((4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylic acid.

What is the molecular formula and molecular weight of Cabozantinib Carboxylic Acid?

Cabozantinib Carboxylic Acid has the molecular formula C22H20N2O6 and a molecular weight of 408.4 g/mol. Its IUPAC name is 1-[[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]carbamoyl]cyclopropane-1-carboxylic acid.

What is Cabozantinib Carboxylic Acid used for?

Cabozantinib Carboxylic Acid is supplied as a characterised reference material related to Cabozantinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Cabozantinib Carboxylic Acid can I order?

We supply Cabozantinib Carboxylic Acid in Reference Standard (94%) grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Cabozantinib Carboxylic Acid?

Yes. Every lot of Cabozantinib Carboxylic Acid is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Cabozantinib Carboxylic Acid be shipped internationally?

Yes. We export Cabozantinib Carboxylic Acid worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.