Trametinib

Name: Trametinib
Brand: Vaqora Chemicals
SKU: VQ-007813

About Trametinib

Vaqora Chemicals supplies Trametinib, a high-purity reference standard of Trametinib registered under CAS number 871700-17-3. Formula C26H23FIN5O4, molecular weight 615.4 g/mol. Alternative names: Mekinist and TMT-212.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Danger” with 4 hazard statements. Review the Safety Data Sheet before use.

As a reference sample of Trametinib, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide. This item is currently in stock for prompt dispatch.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Trametinib

View every impurity, metabolite and intermediate we list for Trametinib.

Trametinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Trametinib
Catalogue No.	VQ-007813
CAS Number	871700-17-3
IUPAC name	N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide
Molecular formula	C₂₆H₂₃FIN₅O₄
Molecular weight	615.4 g/mol
Exact mass	615.0779
Grade	Reference Standard
HSN code	38229090
InChIKey	LIRYPHYGHXZJBZ-UHFFFAOYSA-N
SMILES	CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5
PubChem CID	11707110

Physical properties
Physical form	Solid
LogP (XLogP3)	3.4
H-bond donors / acceptors	2 / 6
TPSA	102 Å²
Synonyms	Mekinist, TMT-212, MEK Inhibitor GSK1120212, Trametinib (GSK1120212), EX-A022, Trametinib (USAN), Trametinib (Standard), Trametinib (GSK1120212JTP 74057), CPD 8B

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H317May cause an allergic skin reaction
H361Suspected of damaging fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure
H373May causes damage to organs through prolonged or repeated exposure

Precautionary statements: P203, P260, P261, P264, P270, P272, P280, P302 + P352, P318, P319, P321, P333 + P317, P362 + P364, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Trametinib?

The CAS Registry Number of Trametinib is 871700-17-3. It is also known as Mekinist, TMT-212, MEK Inhibitor GSK1120212.

What is the molecular formula and molecular weight of Trametinib?

Trametinib has the molecular formula C26H23FIN5O4 and a molecular weight of 615.4 g/mol. Its IUPAC name is N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide.

What is Trametinib used for?

Trametinib is supplied as a characterised reference material related to Trametinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Trametinib can I order?

We supply Trametinib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Trametinib?

Yes. Every lot of Trametinib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Trametinib be shipped internationally?

Yes. Trametinib is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.