Trametinib Impurity 11

Name: Trametinib Impurity 11
Brand: Vaqora Chemicals
SKU: VQ-006060

About Trametinib Impurity 11

Vaqora Chemicals supplies Trametinib Impurity 11, an impurity of Trametinib registered under CAS number 871700-22-0. The compound has the formula C14H13FIN3O2, corresponding to a molecular weight of 401.17 g/mol. Its systematic (IUPAC) name is 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4-dione. Common synonyms include CS-M0421 and 3-cyclopropyl-1-(2-fluoro-4-iodoph.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. It carries the GHS signal word “Danger” with 4 hazard statements. Review the Safety Data Sheet before use.

This Trametinib impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Trametinib Impurity 11 in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide. This item is currently in stock for prompt dispatch.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Trametinib

View every impurity, metabolite and intermediate we list for Trametinib.

Trametinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Trametinib Impurity 11
Catalogue No.	VQ-006060
CAS Number	871700-22-0
IUPAC name	3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4-dione
Molecular formula	C₁₄H₁₃FIN₃O₂
Molecular weight	401.17 g/mol
Exact mass	401.0036
Grade	Reference Standard
HSN code	38229090
InChIKey	MALTZCVPKJAUOE-UHFFFAOYSA-N
SMILES	CNC1=CC(=O)N(C(=O)N1C2=C(C=C(C=C2)I)F)C3CC3
PubChem CID	59717171

Physical properties
Physical form	Solid
LogP (XLogP3)	2.4
H-bond donors / acceptors	1 / 4
TPSA	52.7 Å²
Synonyms	3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)-2,4(1H,3H)-pyrimidinedione, 3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-methylamino-1H-pyrimidine-2,4-dione, 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione, CS-M0421, 3-cyclopropyl-1-(2-fluoro-4-iodoph, 2,4(1H,3H)-Pyrimidinedione, 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)-, 3-cyclopropyl-1-(2-fluoro-4-iodo-phenyl)-6-(methylamino)pyrimidine-2,4-dione

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Trametinib Impurity 11?

The CAS Registry Number of Trametinib Impurity 11 is 871700-22-0. It is also known as 3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)-2,4(1H,3H)-pyrimidinedione, 3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-methylamino-1H-pyrimidine-2,4-dione, 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione.

What is the molecular formula and molecular weight of Trametinib Impurity 11?

Trametinib Impurity 11 has the molecular formula C14H13FIN3O2 and a molecular weight of 401.17 g/mol. Its IUPAC name is 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4-dione.

What is Trametinib Impurity 11 used for?

Trametinib Impurity 11 is supplied as a characterised reference material related to Trametinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Trametinib Impurity 11 can I order?

We supply Trametinib Impurity 11 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Trametinib Impurity 11?

Yes. Every lot of Trametinib Impurity 11 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Trametinib Impurity 11 be shipped internationally?

Yes. Trametinib Impurity 11 is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.