Trametinib Desacetyl Impurity

Name: Trametinib Desacetyl Impurity
Brand: Vaqora Chemicals
SKU: VQ-007269

About Trametinib Desacetyl Impurity

Vaqora Chemicals supplies Trametinib Desacetyl Impurity, a metabolite or degradation product of Trametinib registered under CAS number 871701-87-0 at a purity of 96%. The compound has the formula C24H21FIN5O3, corresponding to a molecular weight of 573.4 g/mol. The IUPAC name is 1-(3-aminophenyl)-3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7-trione. Alternative names: Trametinib, desacetyl and Trametinib metabolite M1.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Good laboratory practice and suitable PPE are recommended during handling.

Analytical teams use this compound to identify metabolites and degradants of Trametinib, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide. This item is currently in stock for prompt dispatch.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Trametinib

View every impurity, metabolite and intermediate we list for Trametinib.

Trametinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Trametinib Desacetyl Impurity
Catalogue No.	VQ-007269
CAS Number	871701-87-0
IUPAC name	1-(3-aminophenyl)-3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7-trione
Molecular formula	C₂₄H₂₁FIN₅O₃
Molecular weight	573.4 g/mol
Exact mass	573.0673
Grade	Reference Standard
Purity / assay	96%
HSN code	38229090
InChIKey	JHOKCEWWVHBOFH-UHFFFAOYSA-N
SMILES	CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)N)C5CC5
PubChem CID	59717278

Physical properties
Physical form	Solid
LogP (XLogP3)	3.6
H-bond donors / acceptors	2 / 6
TPSA	99 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Trametinib Desacetyl Impurity?

The CAS Registry Number of Trametinib Desacetyl Impurity is 871701-87-0. It is also known as Trametinib, desacetyl, Trametinib metabolite M1, Trametinib metabolite M5.

What is the molecular formula and molecular weight of Trametinib Desacetyl Impurity?

Trametinib Desacetyl Impurity has the molecular formula C24H21FIN5O3 and a molecular weight of 573.4 g/mol. Its IUPAC name is 1-(3-aminophenyl)-3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7-trione.

What is Trametinib Desacetyl Impurity used for?

Trametinib Desacetyl Impurity is supplied as a characterised reference material related to Trametinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Trametinib Desacetyl Impurity can I order?

We supply Trametinib Desacetyl Impurity in Reference Standard (96%) grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Trametinib Desacetyl Impurity?

Yes. Every lot of Trametinib Desacetyl Impurity is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Trametinib Desacetyl Impurity be shipped internationally?

Yes. We export Trametinib Desacetyl Impurity worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.