Trametinib Hydroxy Impurity

Name: Trametinib Hydroxy Impurity
Brand: Vaqora Chemicals
SKU: VQ-006059

About Trametinib Hydroxy Impurity

Vaqora Chemicals supplies Trametinib Hydroxy Impurity, an impurity of Trametinib registered under CAS number 871700-24-2. The compound has the formula C18H15FIN3O4, corresponding to a molecular weight of 483.2 g/mol. The IUPAC name is 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7-trione. Common synonyms include Trametinib INT and cyclopropylthiadiazolamine.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Good laboratory practice and suitable PPE are recommended during handling.

Pharmaceutical QC and development laboratories use this impurity standard of Trametinib to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg and 50 mg packs, Trametinib Hydroxy Impurity is dispatched with a Certificate of Analysis (COA) to destinations worldwide. Stock is available for quick dispatch.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Trametinib

View every impurity, metabolite and intermediate we list for Trametinib.

Trametinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Trametinib Hydroxy Impurity
Catalogue No.	VQ-006059
CAS Number	871700-24-2
IUPAC name	3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7-trione
Molecular formula	C₁₈H₁₅FIN₃O₄
Molecular weight	483.2 g/mol
Exact mass	483.0091
Grade	Reference Standard
HSN code	38229090
InChIKey	MHHFXMZMCYWCJQ-UHFFFAOYSA-N
SMILES	CC1=C(C2=C(N(C1=O)C)N(C(=O)N(C2=O)C3CC3)C4=C(C=C(C=C4)I)F)O
PubChem CID	59717004

Physical properties
Physical form	Solid
LogP (XLogP3)	2.4
H-bond donors / acceptors	1 / 5
TPSA	81.2 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Trametinib Hydroxy Impurity?

The CAS Registry Number of Trametinib Hydroxy Impurity is 871700-24-2. It is also known as Trametinib INT, cyclopropylthiadiazolamine, CS-M0422.

What is the molecular formula and molecular weight of Trametinib Hydroxy Impurity?

Trametinib Hydroxy Impurity has the molecular formula C18H15FIN3O4 and a molecular weight of 483.2 g/mol. Its IUPAC name is 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7-trione.

What is Trametinib Hydroxy Impurity used for?

Trametinib Hydroxy Impurity is supplied as a characterised reference material related to Trametinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Trametinib Hydroxy Impurity can I order?

We supply Trametinib Hydroxy Impurity in Reference Standard grade, in 10 mg, 25 mg, 50 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Trametinib Hydroxy Impurity?

Yes. Every lot of Trametinib Hydroxy Impurity is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Trametinib Hydroxy Impurity be shipped internationally?

Yes. We export Trametinib Hydroxy Impurity worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.