3-Amino-4-hydroxybenzoic acid

About 3-Amino-4-hydroxybenzoic acid

3-Amino-4-hydroxybenzoic acid is a metabolite or degradation product of Methotrexate carrying the CAS registry number 1571-72-8. Its molecular formula is C7H7NO3 and its molecular weight is 153.14 g/mol. It is also known as Benzoic acid, 3-amino-4-hydroxy- or 3,4-AHBA.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Warning” with 4 hazard statements. Review the Safety Data Sheet before use.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Methotrexate, as well as in QC testing and ANDA/DMF documentation. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 3-Amino-4-hydroxybenzoic acid is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Methotrexate

View every impurity, metabolite and intermediate we list for Methotrexate.

Methotrexate impurities

Specifications & identifiers

Chemical identifiers
Product name	3-Amino-4-hydroxybenzoic acid
Catalogue No.	VQ-039347
CAS Number	1571-72-8
IUPAC name	3-amino-4-hydroxybenzoic acid
Molecular formula	C₇H₇NO₃
Molecular weight	153.14 g/mol
Exact mass	153.0426
Grade	Reference Standard
HSN code	38229090
InChIKey	MRBKRZAPGUCWOS-UHFFFAOYSA-N
SMILES	C1=CC(=C(C=C1C(=O)O)N)O
PubChem CID	65083

Physical properties
Physical form	Solid
LogP (XLogP3)	0.7
H-bond donors / acceptors	3 / 4
TPSA	83.6 Å²
Synonyms	Benzoic acid, 3-amino-4-hydroxy-, 3,4-AHBA, 4-hydroxy-3-aminobenzoic acid, 1H-Indole,4,5-difluoro-2-methyl-, 3-amino-4-hydroxybenzenecarboxylic acid

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 3-Amino-4-hydroxybenzoic acid?

The CAS Registry Number of 3-Amino-4-hydroxybenzoic acid is 1571-72-8. It is also known as Benzoic acid, 3-amino-4-hydroxy-, 3,4-AHBA, 4-hydroxy-3-aminobenzoic acid.

What is the molecular formula and molecular weight of 3-Amino-4-hydroxybenzoic acid?

3-Amino-4-hydroxybenzoic acid has the molecular formula C7H7NO3 and a molecular weight of 153.14 g/mol. Its IUPAC name is 3-amino-4-hydroxybenzoic acid.

What is 3-Amino-4-hydroxybenzoic acid used for?

3-Amino-4-hydroxybenzoic acid is supplied as a characterised reference material related to Methotrexate. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 3-Amino-4-hydroxybenzoic acid can I order?

We supply 3-Amino-4-hydroxybenzoic acid in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 3-Amino-4-hydroxybenzoic acid?

Yes. Every lot of 3-Amino-4-hydroxybenzoic acid is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 3-Amino-4-hydroxybenzoic acid be shipped internationally?

Yes. 3-Amino-4-hydroxybenzoic acid is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.