Methotrexate EP Impurity J

Name: Methotrexate EP Impurity J
Brand: Vaqora Chemicals
SKU: VQ-021277

About Methotrexate EP Impurity J

Methotrexate EP Impurity J (CAS 34378-65-9) is a pharmacopeial impurity of Methotrexate offered by Vaqora Chemicals. Formula C22H26N8O5, molecular weight 482.5 g/mol. Its systematic (IUPAC) name is dimethyl (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioate. Alternative names: Methotrexate Dimethylester Hydrochloride and Methotrexate - Impurity J.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Pharmaceutical QC and development laboratories use this impurity standard of Methotrexate to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Methotrexate

View every impurity, metabolite and intermediate we list for Methotrexate.

Methotrexate impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Methotrexate EP Impurity J
Catalogue No.	VQ-021277
CAS Number	34378-65-9
IUPAC name	dimethyl (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioate
Molecular formula	C₂₂H₂₆N₈O₅
Molecular weight	482.5 g/mol
Exact mass	482.2026
Grade	Reference Standard
HSN code	38229090
InChIKey	DIQFVFAFHNQUTG-HNNXBMFYSA-N
SMILES	CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)OC)C(=O)OC
PubChem CID	118159

Physical properties
Physical form	Solid
LogP (XLogP3)	0.2
H-bond donors / acceptors	3 / 12
TPSA	189 Å²
Synonyms	Methotrexate Dimethylester Hydrochloride, Methotrexate - Impurity J, Methotrexate Dimethyl Ester, Dimethyl methotrexate, (S)-Dimethyl 2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Methotrexate EP Impurity J?

The CAS Registry Number of Methotrexate EP Impurity J is 34378-65-9. It is also known as Methotrexate Dimethylester Hydrochloride, Methotrexate - Impurity J, Methotrexate Dimethyl Ester.

What is the molecular formula and molecular weight of Methotrexate EP Impurity J?

Methotrexate EP Impurity J has the molecular formula C22H26N8O5 and a molecular weight of 482.5 g/mol. Its IUPAC name is dimethyl (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioate.

What is Methotrexate EP Impurity J used for?

Methotrexate EP Impurity J is supplied as a characterised reference material related to Methotrexate. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Methotrexate EP Impurity J can I order?

We supply Methotrexate EP Impurity J in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Methotrexate EP Impurity J?

Yes. Every lot of Methotrexate EP Impurity J is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Methotrexate EP Impurity J be shipped internationally?

Yes. We export Methotrexate EP Impurity J worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.