Methotrexate γ-Ethyl Ester

Name: Methotrexate γ-Ethyl Ester
Brand: Vaqora Chemicals
SKU: VQ-035345

About Methotrexate γ-Ethyl Ester

Listed under CAS 65148-64-3, Methotrexate γ-Ethyl Ester is an impurity of Methotrexate available from Vaqora Chemicals. Its molecular formula is C22H26N8O5 and its molecular weight is 482.5 g/mol. The IUPAC name is (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-5-ethoxy-5-oxopentanoic acid. Common synonyms include gamma-Monoethyl methotrexate and Methotrexate gamma-monoethyl ester.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Good laboratory practice and suitable PPE are recommended during handling.

As a characterised impurity of Methotrexate, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Methotrexate γ-Ethyl Ester in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Methotrexate

View every impurity, metabolite and intermediate we list for Methotrexate.

Methotrexate impurities

Specifications & identifiers

Chemical identifiers
Product name	Methotrexate γ-Ethyl Ester
Catalogue No.	VQ-035345
CAS Number	65148-64-3
IUPAC name	(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-5-ethoxy-5-oxopentanoic acid
Molecular formula	C₂₂H₂₆N₈O₅
Molecular weight	482.5 g/mol
Exact mass	482.2026
Grade	Reference Standard
HSN code	38229090
InChIKey	CYBKLZCFMQQPOM-HNNXBMFYSA-N
SMILES	CCOC(=O)CC[C@@H](C(=O)O)NC(=O)C1=CC=C(C=C1)N(C)CC2=CN=C3C(=N2)C(=NC(=N3)N)N
PubChem CID	90672326

Physical properties
Physical form	Solid
LogP (XLogP3)	-1.2
H-bond donors / acceptors	4 / 12
TPSA	200 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Methotrexate γ-Ethyl Ester?

The CAS Registry Number of Methotrexate γ-Ethyl Ester is 65148-64-3. It is also known as gamma-Monoethyl methotrexate, Methotrexate gamma-monoethyl ester.

What is the molecular formula and molecular weight of Methotrexate γ-Ethyl Ester?

Methotrexate γ-Ethyl Ester has the molecular formula C22H26N8O5 and a molecular weight of 482.5 g/mol. Its IUPAC name is (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-5-ethoxy-5-oxopentanoic acid.

What is Methotrexate γ-Ethyl Ester used for?

Methotrexate γ-Ethyl Ester is supplied as a characterised reference material related to Methotrexate. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Methotrexate γ-Ethyl Ester can I order?

We supply Methotrexate γ-Ethyl Ester in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Methotrexate γ-Ethyl Ester?

Yes. Every lot of Methotrexate γ-Ethyl Ester is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Methotrexate γ-Ethyl Ester be shipped internationally?

Yes. We export Methotrexate γ-Ethyl Ester worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.