Methotrexate EP Impurity E Hydrochloride

Name: Methotrexate EP Impurity E Hydrochloride
Brand: Vaqora Chemicals
SKU: VQ-031823

About Methotrexate EP Impurity E Hydrochloride

Methotrexate EP Impurity E Hydrochloride is a pharmacopeial impurity of Methotrexate carrying the CAS registry number 70844-48-3. Formula C30H31ClN14O4, molecular weight 687.1 g/mol. Alternative names: Methotrexate EP Impurity E and Methotrexate - Impurity E (HCl Salt).

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

As a characterised impurity of Methotrexate, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

We offer Methotrexate EP Impurity E Hydrochloride in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Methotrexate

View every impurity, metabolite and intermediate we list for Methotrexate.

Methotrexate impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Methotrexate EP Impurity E Hydrochloride
Catalogue No.	VQ-031823
CAS Number	70844-48-3
IUPAC name	bis(4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoic acid);hydrochloride
Molecular formula	C₃₀H₃₁ClN₁₄O₄
Molecular weight	687.1 g/mol
Exact mass	686.2341
Grade	Reference Standard
HSN code	38229090
InChIKey	WWFYKUISNIJHNQ-UHFFFAOYSA-N
SMILES	CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)O.CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)O.Cl
PubChem CID	66957731

Physical properties
Physical form	Solid
H-bond donors / acceptors	7 / 18
TPSA	288 Å²
Synonyms	Methotrexate EP Impurity E, Methotrexate - Impurity E (HCl Salt), 4-Amino-4-deoxy-N10-methylpteroic acid, hemihydrochloride, Benzoic acid, 4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)-, hydrochloride (2:1), hemihydrochloride4-amino-4-deoxy-N10-methylpteroic acid, 4-[N-(2,4-diamino-6-pteridinylmethyl)-N-methylamino]benzoic acid hemihydrochloride

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H317May cause an allergic skin reaction

Precautionary statements: P261, P272, P280, P302 + P352, P321, P333 + P317, P362 + P364, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Methotrexate EP Impurity E Hydrochloride?

The CAS Registry Number of Methotrexate EP Impurity E Hydrochloride is 70844-48-3. It is also known as Methotrexate EP Impurity E, Methotrexate - Impurity E (HCl Salt), 4-Amino-4-deoxy-N10-methylpteroic acid, hemihydrochloride.

What is the molecular formula and molecular weight of Methotrexate EP Impurity E Hydrochloride?

Methotrexate EP Impurity E Hydrochloride has the molecular formula C30H31ClN14O4 and a molecular weight of 687.1 g/mol.

What is Methotrexate EP Impurity E Hydrochloride used for?

Methotrexate EP Impurity E Hydrochloride is supplied as a characterised reference material related to Methotrexate. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Methotrexate EP Impurity E Hydrochloride can I order?

We supply Methotrexate EP Impurity E Hydrochloride in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Methotrexate EP Impurity E Hydrochloride?

Yes. Every lot of Methotrexate EP Impurity E Hydrochloride is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Methotrexate EP Impurity E Hydrochloride be shipped internationally?

Yes. Methotrexate EP Impurity E Hydrochloride is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.