Promethazine EP Impurity D

Name: Promethazine EP Impurity D
Brand: Vaqora Chemicals
SKU: VQ-033349

About Promethazine EP Impurity D

Promethazine EP Impurity D (CAS 7640-51-9) is a pharmacopeial impurity of Promethazine offered by Vaqora Chemicals. Formula C17H20N2OS, molecular weight 300.4 g/mol. The IUPAC name is N,N-dimethyl-1-(5-oxophenothiazin-10-yl)propan-2-amine. It is also known as Promethazine Sulfoxide or Promethazine EP Impurity D Hydrochloride.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Promethazine to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

We offer Promethazine EP Impurity D in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Promethazine

View every impurity, metabolite and intermediate we list for Promethazine.

Promethazine impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Promethazine EP Impurity D
Catalogue No.	VQ-033349
CAS Number	7640-51-9
IUPAC name	N,N-dimethyl-1-(5-oxophenothiazin-10-yl)propan-2-amine
Molecular formula	C₁₇H₂₀N₂OS
Molecular weight	300.4 g/mol
Exact mass	300.1296
Grade	Reference Standard
HSN code	38229090
InChIKey	OWTCLFIFAFHQIX-UHFFFAOYSA-N
SMILES	CC(CN1C2=CC=CC=C2S(=O)C3=CC=CC=C31)N(C)C
PubChem CID	63032

Physical properties
Physical form	Solid
LogP (XLogP3)	3.5
H-bond donors / acceptors	0 / 3
TPSA	53.5 Å²
Synonyms	Promethazine Sulfoxide, Promethazine EP Impurity D Hydrochloride, Promethazine Hydrochloride - Impurity D, Romergan sulfoxide, 10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl-, 5-oxide, 10-(2-(Dimethylamino)propyl)-10H-phenothiazine 5-oxide, Promethazine 5-Oxide, 10-(2-(Dimethylamino)propyl)-10H-phenothiazine5-oxide, N-[2-(Dimethylamino)propyl]phenothiazine S-Oxide, 10-[2-(Dimethylamino)propyl]-10H-phenothiazine 5-Oxide, Promethazine 5-Sulfoxide, N,N,alpha-Trimethyl-10H-phenothiazine-10-ethanamine 5-oxide

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements: P264, P270, P301 + P317, P330, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Promethazine EP Impurity D?

The CAS Registry Number of Promethazine EP Impurity D is 7640-51-9. It is also known as Promethazine Sulfoxide, Promethazine EP Impurity D Hydrochloride, Promethazine Hydrochloride - Impurity D.

What is the molecular formula and molecular weight of Promethazine EP Impurity D?

Promethazine EP Impurity D has the molecular formula C17H20N2OS and a molecular weight of 300.4 g/mol. Its IUPAC name is N,N-dimethyl-1-(5-oxophenothiazin-10-yl)propan-2-amine.

What is Promethazine EP Impurity D used for?

Promethazine EP Impurity D is supplied as a characterised reference material related to Promethazine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Promethazine EP Impurity D can I order?

We supply Promethazine EP Impurity D in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Promethazine EP Impurity D?

Yes. Every lot of Promethazine EP Impurity D is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Promethazine EP Impurity D be shipped internationally?

Yes. Promethazine EP Impurity D is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.