Topotecan

Name: Topotecan
Brand: Vaqora Chemicals
SKU: VQ-004221

About Topotecan

Topotecan (CAS 123948-87-8) is an anticancer API offered by Vaqora Chemicals in IP/BP/USP grade. Its molecular formula is C23H23N3O5 and its molecular weight is 421.4 g/mol. It is also known as Hycamptamine or Topotecan lactone.

The product is provided as a powder. Keep the container tightly sealed and store it in a cool, dry area. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

As an active pharmaceutical ingredient within our oncology APIs range, it is offered in IP/BP/USP grade for formulation development, generic drug programmes and commercial manufacturing. Typical end-use sectors are pharmaceutical manufacturing.

We offer Topotecan in 1 kg, 5 kg and 25 kg packs with a batch-specific COA, and ship to customers worldwide. A Safety Data Sheet (SDS) and technical specifications are available on request.

Typical applications

Polymer & resin production
Pharmaceutical formulation

Industries

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Topotecan
Catalogue No.	VQ-004221
CAS Number	123948-87-8
IUPAC name	(19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione
Molecular formula	C₂₃H₂₃N₃O₅
Molecular weight	421.4 g/mol
Exact mass	421.1638
Grade	IP/BP/USP
HSN code	2933
InChIKey	UCFGDBYHRUNTLO-QHCPKHFHSA-N
SMILES	CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O
PubChem CID	60700

Physical properties
Physical form	Powder
LogP (XLogP3)	0.5
H-bond donors / acceptors	2 / 7
TPSA	103 Å²
Synonyms	Hycamptamine, Topotecan lactone, Hycamptin, Topotecane, (S)-Topotecan, Topophore C, 9-Dimethylaminomethyl-10-hydroxycamptothecin, FF-10850 (liposomal topotecan), 9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin, 9-((dimethylamino)methyl)-10-hydroxy-(4S)-camptothecin, 9 Dimethylaminomethyl 10 hydroxycamptothecin, 9-((dimethylamino)methyl)-10-hydroxy-(20S)-camptothecin

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H340May cause genetic defects
H341Suspected of causing genetic defects

Precautionary statements: P203, P261, P264, P264 + P265, P270, P271, P280, P301 + P316, P302 + P352, P304 + P340, P305 + P351 + P338, P318, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Topotecan?

The CAS Registry Number of Topotecan is 123948-87-8. It is also known as Hycamptamine, Topotecan lactone, Hycamptin.

What is the molecular formula and molecular weight of Topotecan?

Topotecan has the molecular formula C23H23N3O5 and a molecular weight of 421.4 g/mol.

Which grade and pack sizes of Topotecan can I order?

We supply Topotecan in IP/BP/USP grade, in 1 kg, 5 kg, 25 kg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Topotecan?

Yes. Every lot of Topotecan is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Topotecan be shipped internationally?

Yes. Topotecan is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.