Impurity reference standards
Osimertinib impurities & reference standards
Characterised Osimertinib impurities, degradation products and related compounds for analytical method development, validation, QC release and regulatory filings.
48reference materials
2nitrosamine impurities
1isotope-labelled
COAHPLC · NMR · MS on request
Parent API: Osimertinib
1421373-65-0 · C28H33N7O2
2-Methoxy-N4-methyl-N1-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-5-nitrobenzene-1,4-diamine
- CAS
- 2044704-62-1
- Formula
- C21H20N6O3
- MW
- 404.4 g/mol
VQ-038816
2-Methoxy-N4,N4-dimethyl-N1-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-5-nitrobenzene-1,4-diamine
- CAS
- 1820891-36-8
- Formula
- C22H22N6O3
- MW
- 418.4 g/mol
VQ-032305
3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole
- CAS
- 1032452-86-0
- Formula
- C13H10ClN3
- MW
- 243.69 g/mol
VQ-038814
3,3`-(Pyrimidine-2,4-diyl)bis(1-methyl-1H-indole)
- CAS
- 2364486-24-6
- Formula
- C22H18N4
- MW
- 338.4 g/mol
VQ-049358
5-Methoxy-N1,N1-dimethyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine hydrochloride
- CAS
- 2044702-55-6
- Formula
- C22H25ClN6O
- MW
- 424.9 g/mol
VQ-032311
N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-N-(3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)-3-oxopropyl)acrylamide
- CAS
- 2919324-18-6
- Formula
- C56H66N14O4
- MW
- 999.2 g/mol
VQ-038812
N-(2-((2-Acrylamido-5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)(methyl)amino)ethyl)-3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)-N,N-dimethyl-3-oxopropan-1-aminium
- CAS
- 2564638-97-5
- Formula
- C56H67N14O4+
- MW
- 1000.2 g/mol
VQ-027060
N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine
- CAS
- 1421372-94-2
- Formula
- C20H16FN5O3
- MW
- 393.4 g/mol
VQ-013606
N-(5-((4-(1H-Indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide
- CAS
- 1421373-98-9
- Formula
- C27H31N7O2
- MW
- 485.6 g/mol
VQ-027056
N1,N5-Bis(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-2-methylenepentanediamide
- CAS
- 2945220-41-5
- Formula
- C56H66N14O4
- MW
- 999.2 g/mol
VQ-032310
![N4-(4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)pyrimidin-2-yl)-N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methylbenzene-1,2,4-triamine](/media/pack/n4-4-56-dihydro-4h-pyrrolo321-ijquinolin-1-ylpyrimidin-2-yl-n1-2-dimethylaminoethyl-5.svg?v=3)
N4-(4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)pyrimidin-2-yl)-N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methylbenzene-1,2,4-triamine
- CAS
- 1825290-88-7
- Formula
- C27H33N7O
- MW
- 471.6 g/mol
VQ-049363
O-Des Methyl Osimertinib Intermediate (Stage-1)
- CAS
- 1801616-73-8
- Formula
- C20H18FN5O
- MW
- 363.4 g/mol
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FAQs — Osimertinib impurities
Which Osimertinib impurities do you supply?
We list 48 Osimertinib-related reference materials, including process impurities, degradation products, nitrosamine impurities, stable-isotope-labelled standards and related compounds. Each is supplied with a COA, and characterisation data (HPLC, 1H-NMR, MS, IR) can be provided on request.
What are Osimertinib impurity standards used for?
They are used for analytical method development and validation, impurity identification and quantification, forced-degradation and stability studies, and to support ANDA, DMF and other regulatory submissions under ICH Q3A/Q3B (and ICH M7 for mutagenic impurities).
Can you synthesise a Osimertinib impurity that is not listed?
Yes. Our custom synthesis service can prepare and characterise unlisted impurities, metabolites and labelled analogues from milligram to gram scale. Share the structure or name and required quantity for a quotation.
Request Osimertinib impurity standards
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